Ofloxacin Tablets 200 mg – Uses, Side Effects, and Precautions
Introduction
Ofloxacin Tablets 200 mg is a broad-spectrum antibiotic that belongs to the fluoroquinolone class of drugs. It is widely prescribed for bacterial infections, targeting both gram-positive and gram-negative bacteria. This medication is highly effective in treating infections of the respiratory tract, urinary tract, skin, soft tissues, and gastrointestinal system.
Composition & Mechanism of Action
Composition:
- Active Ingredient: Ofloxacin 200 mg
- Dosage Form: Tablet
- Category: Antibiotic
Mechanism of Action:
Ofloxacin works by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes essential for bacterial DNA replication, transcription, and repair. This results in bacterial cell death, effectively treating the infection.
Uses & Indications
Ofloxacin 200 mg is prescribed for the treatment of various bacterial infections, including:
1. Respiratory Tract Infections
- Bronchitis
- Pneumonia
- Sinusitis
2. Urinary Tract Infections (UTIs)
- Cystitis (bladder infection)
- Pyelonephritis (kidney infection)
3. Skin & Soft Tissue Infections
- Cellulitis
- Abscesses
- Wound infections
4. Gastrointestinal Infections
- Traveler’s diarrhea
- Bacterial dysentery
- Typhoid fever
5. Sexually Transmitted Infections (STIs)
- Gonorrhea
- Chlamydia
6. Ear & Eye Infections
- Bacterial conjunctivitis
- Otitis media (middle ear infection)
Dosage & Administration
Recommended Dosage:
- Adults: 200-400 mg per day in divided doses (depending on severity).
- Children: Not commonly prescribed; only recommended if necessary under medical supervision.
- Elderly: Dosage may be adjusted based on kidney function.
Administration Guidelines:
- Take before or after meals with a full glass of water.
- Avoid dairy products, calcium-fortified juices, and antacids within 2 hours of taking Ofloxacin, as they can reduce absorption.
- Complete the full course of treatment to prevent antibiotic resistance.
Side Effects & Precautions
Common Side Effects:
- Nausea & vomiting
- Diarrhea
- Headache
- Dizziness
- Abdominal pain
Serious Side Effects (Seek Medical Attention Immediately):
- Tendon rupture or pain
- Severe allergic reactions (rash, swelling, difficulty breathing)
- Neurological effects (seizures, hallucinations)
- Liver dysfunction (yellowing of skin/eyes, dark urine)
Precautions:
- Avoid direct sunlight exposure (risk of photosensitivity).
- Not recommended for pregnant or breastfeeding women.
- Use caution in patients with a history of seizures or kidney disease.
Drug Interactions
Ofloxacin 200 mg can interact with several medications, including:
- NSAIDs (Ibuprofen, Aspirin): Increases the risk of seizures.
- Antacids & Iron Supplements: Reduces absorption of Ofloxacin.
- Blood Thinners (Warfarin): Increases the risk of bleeding.
- Corticosteroids: Increases the risk of tendon damage.
Storage & Handling
- Store at room temperature (15-25°C) in a dry place.
- Keep away from moisture, heat, and direct sunlight.
- Keep out of reach of children.
Conclusion
Ofloxacin 200 mg is a highly effective antibiotic used for a wide range of bacterial infections. It is crucial to follow proper dosage, precautions, and doctor’s recommendations to ensure safe and effective treatment. Always complete the full course to prevent antibiotic resistance.
